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Shield for the body, enhancing Innate Immunity.

It has a positive impact on the composition of plasma immunoglobulin

2'-FLgroup's rats show higher levels of IgG and IgA, and the TH1/Th2 ratio increases, which indicates that 2 '-FL promotes the maturity of the early life immune system in the early life of life.

Can adjust the proportion of immune cell groups in enteric lymph nodes

Feed 2'-FL's Rice T cells/B cells increased, and the proportion of cd8+ γΔ T cells increased, which shows that 2 '-FL accelerates the maturity of intestinal immune cells

Can effectively alleviate allergies caused by β-milk globulin in milk

Li Chun and others in Northeast Agricultural University proved that 2'-FL can effectively alleviate the allergic reactions caused by β-LG through the mouse model.

Can effectively alleviate allergies caused by ovard protein in eggs

Continuous oral OVA can cause severe diarrhea in mice. Treatment with 2'-FL can significantly reduce diarrhea caused by OVA stimuli

Assist cognitive development, contribute to intellectual abilities.

Horse Horse gene expression upward adjustment

Stephen A. Fleming et al., The University of Illinois, evaluated the impact of feeding 2'-FL's expression of MRNA in 93 genes in animal hippocampus tissues.

Hippocampus synapse signal transmission is enhanced

Learning and memory are adjusted through changes in the intensity of synapses between neurons. A study by the University of Olavid, Spain, the impact of 2'-FL on the synapses of hippocampus.

Y maze testing performance is better

Studies found that 2'-FL groups of rats explored shorter latent periods of the new maze arm (Figure 5 A), and the proportion of new maze arms (Figure 5B) has a better performance in the Y maze test.

New object recognition (NOR) ability enhancement

2'-FL group of rats has greater interest in new objects than old objects, which shows that they can recognize and remember familiar objects.

Natural intestinal barrier, promoting healthy growth.

Baby intestinal microorganisms are closer to breastfeeding

Africa containing HMO formula milk powder, its intestinal microorganisms are closer to breastfeeding (BF) group at the level

Promote the growth of beneficial bacteria and inhibit Harmful bacteria growth

2'-FL treatment has increased significantly at 48h at 48h, and the level of harmful bacteria and other harmful bacteria and other harmful bacteria are significantly reduced.

Improve the content of short -chain fatty acids

2'-FL treatment significantly improves the content of short chain fatty acids in the stool of colonitis mice, making it close to normal levels.

Maintain the number of intestinal cup -shaped cells

Compared with normal mice, the number of cup-shaped cells in colon of colon is very small, while 2'-FL treats more cup-like cells in the colon.

Natural intestinal barrier, resisting intestinal diseases.

Reduce the internal organs of colitis mice

Experiments show that DSS-induced colitis mice have obvious spleen swelling. After treatment with 2’-FL, the degree of swelling and spleen coefficient of the spleen are significantly reduced.

Relieve stomanitis symptoms

Histopathological observation showed that 2'-FL reduced the severity of DSS-induced crypt damage, inflammatory infiltration, and colon inflammation in mice, and alleviated inflammatory symptoms.

Increase the relative abundance of Bifidobacterium

The relative abundance of intestinal microorganisms in patients with IBS changes, with a decrease in the number of mucosal Bacteroidetes and an increase in the relative abundance of fecal and mucosal Bifidobacterium.

Reduce symptoms of irritable bowel syndrome

The overall severity of symptoms has significantly decreased, with significant improvements in the severity of abdominal pain and bloating, and there is no difference in the reduction effect between different subtypes of IBS.

References:

[1]Ignasi Azagra-Boronat, et al. "Immunomodulatory and Prebiotic Effects of 2′-Fucosyllactose in Suckling Rats. " Frontiers in Immunology 10(2019).

[2] Li, Aili , et al. "The human milk oligosaccharide 2’-fucosyllactose attenuates β-lactoglobulin-induced food allergy through the miR-146a-mediated toll-like receptor 4/nuclear factor-κB signaling pathway." Journal of dairy science 104.10(2021):10473-10484.

[3] L. Castillo-Courtade, et al. "Attenuation of food allergy symptoms following treatment with human milk oligosaccharides in a mouse model." Allergy 70.9(2015):1091-1102.

[4]Vázquez, Enrique, et al. "Effects of a human milk oligosaccharide, 2′-fucosyllactose, on hippocampal long-term potentiation and learning capabilities in rodents." Journal of Nutritional Biochemistry 26.5(2015):455-465.

[5] Oliveros, Elena , et al. "Oral supplementation of 2′-fucosyllactose during lactation improves memory and learning in rats." Journal of Nutritional Biochemistry 31(2016):20-27.

[6] Fleming, Stephen A. , et al. "Dietary Oligofructose Alone or in Combination with 2′-Fucosyllactose Differentially Improves Recognition Memory and Hippocampal mRNA Expression." Nutrients 12.7(2020):2131.

[7] Docq, Sylvia , et al. "The Protective and Long-Lasting Effects of Human Milk Oligosaccharides on Cognition in Mammals." Nutrients 12.11(2020).

[8] Berger, Bernard, et al. "Linking human milk oligosaccharides, infant fecal community types, and later risk to require antibiotics." MBio 11.2 (2020): 10-1128.

[9] Vigsnaes, Louise Kristine, et al. "2′ FL and LNnT exert antipathogenic effects against C. difficile ATCC 9689 in vitro, coinciding with increased levels of bifidobacteriaceae and/or secondary bile acids." Pathogens 10.8 (2021): 927.

[10] Lv, Huiqing, et al. "The protective effect of 2’-Fucosyllactose on LPS-induced colitis suckling mice by ameliorating intestinal inflammation and modulating gut microbiota." Food Bioscience 51 (2023): 102317.

[11] Liu, Xiaoxia, et al. "Differential responses on gut microbiota and microbial metabolome of 2′-fucosyllactose and galactooligosaccharide against DSS-induced colitis." Food Research International 162 (2022): 112072.

[12] 黄则华, 等."肠道菌群对黏蛋白2的影响及其作用机制." 胃肠病学 24.02(2019):111-114.

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